Synthesis of peptide derivative as bio adhesive

Bio adhesive material is a protein adhesive, which has recently been highlighted as an attractive biologically based and highly functional adhesive as a new chemo enzymatic synthesis of co polypeptide. The bio adhesive polymer was prepared by modification of pepsin structure with vinyl monomer such as maleic anhydride using ceric ammonium nitrate as an initiator, then the grafted copolymer was substituted with amino drugs. This design carries controlled delivery over an extended period of time due to its digesting nature. The new drug copolymer was investigated using common spectroscopy methods, such as FTIR, ¹H-NMR and UV Spectroscopy. The physical properties for the prepared polymers were tested. Our results show that deprotonated is required for drug copolymers when analyzed in different pH values at 37 °C in vitro study and controlled drug release was compared at zero time and after three days. The rate of hydrolysis in basic medium was higher than acidic medium. It was concluded There are several advantages of sustain release by modified drug with slow release and in vivo performance was noted to be promising using for applications of polymer used different mice and rabbits infected with bacteria and wounds. (paper)