Published December 1977
| Version v1
Journal article
Studies of tumor metabolism
- 1. Argonne National Lab., Ill. (USA)
Description
57Co-bleomycin has biological properties which are suitable for clinical use as a tumour/scanning agent. The Moessbauer spectroscopic technique has been used to investigate the chemical bonding of 57Co-bleomycin in vitro compared with that observed for 57Co-bleomycin which had become localized in a tumour. The results indicated that the 57Co-bleomycin was injected as a mixture of Co(II) and Co(III) complexes. When the Co-bleomycin complex was metabolized by the tumour, it was localized as primarily a Co(III) species. Possible metabolic pathways are briefly discussed. (U.K.)
Additional details
Additional titles
- Subtitle (English)
- 2. Moessbauer spectroscopy of "5"7Co-bleomycin
Identifiers
Publishing Information
- Journal Title
- International Journal of Nuclear Medicine and Biology
- Journal Volume
- 4
- Journal Issue
- 3-4
- Series
- Int. J. Nucl. Med. Biol.
- Journal Page Range
- 216-218
- ISSN
- 0047-0740
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 9373635
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL LOCALIZATION; BLEOMYCIN; COBALT COMPLEXES; COBALT 57; COMPARATIVE EVALUATIONS; IN VITRO; IN VIVO; METABOLISM; MOESSBAUER EFFECT; NEOPLASMS; RADIOPHARMACEUTICALS; STRUCTURAL CHEMICAL ANALYSIS; VALENCE
- Descriptors DEC
- ANTIBIOTICS; ANTIMITOTIC DRUGS; BETA DECAY RADIOISOTOPES; COBALT ISOTOPES; COMPLEXES; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; LABELLED COMPOUNDS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; TRANSITION ELEMENT COMPLEXES
Optional Information
- Notes
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