The role of hyperpolarized ¹²⁹xenon in MR imaging of pulmonary function

Highlights: • Recent advances in hyperpolarized 129Xe MRI are reviewed. • Xenon MRI allows for functional imaging of ventilation, diffusion, and gas exchange. • Xenon's unique gas exchange imaging capabilities are highlighted. • Applications to obstructive and restrictive lung diseases are presented. • These advances are ready for translation to clinical applications. - Abstract: In the last two decades, functional imaging of the lungs using hyperpolarized noble gases has entered the clinical stage. Both helium (³He) and xenon (¹²⁹Xe) gas have been thoroughly investigated for their ability to assess both the global and regional patterns of lung ventilation. With advances in polarizer technology and the current transition towards the widely available ¹²⁹Xe gas, this method is ready for translation to the clinic. Currently, hyperpolarized (HP) noble gas lung MRI is limited to selected academic institutions; yet, the promising results from initial clinical trials have drawn the attention of the pulmonary medicine community. HP ¹²⁹Xe MRI provides not only 3-dimensional ventilation imaging, but also unique capabilities for probing regional lung physiology. In this review article, we aim to (1) provide a brief overview of current ventilation MR imaging techniques, (2) emphasize the role of HP ¹²⁹Xe MRI within the array of different imaging strategies, (3) discuss the unique imaging possibilities with HP ¹²⁹Xe MRI, and (4) propose clinical applications.