Published November 2018 | Version v1
Journal article Metadata-only

Regional Radiation Dose-Response Modeling of Functional Liver in Hepatocellular Carcinoma Patients With Longitudinal Sulfur Colloid SPECT/CT: A Proof of Concept

Creators

  • 1. Department of Radiation Oncology, University of Washington School of Medicine, Seattle (United States)
  • 2. Department of Radiology, University of Washington School of Medicine, Seattle (United States)
  • 3. Beth-Israel Deaconess Medical Center, Department of Radiation Oncology, Harvard Medical School, Boston (United States)

Description

Hepatotoxicity risk in patients with hepatocellular carcinoma (HCC) is modulated by radiation dose delivered to normal liver tissue, but reported dose-response data are limited. Our prior work established baseline [99mTc]sulfur colloid (SC) single-photon emission computed tomography (SPECT)/computed tomography (CT) liver function imaging biomarkers that predict clinical outcomes. We conducted a proof-of-concept investigation with longitudinal SC SPECT/CT to characterize patient-specific radiation dose-response relationships as surrogates for liver radiosensitivity.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.ijrobp.2018.06.017

Additional details

Identifiers

DOI
10.1016/j.ijrobp.2018.06.017;
PII
S0360301618310083;

Publishing Information

Journal Title
International Journal of Radiation Oncology, Biology and Physics
Journal Volume
102
Journal Issue
4
Journal Page Range
p. 1349-1356
ISSN
0360-3016
CODEN
IOBPD3

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
54107085
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BIOLOGICAL MARKERS; COLLOIDS; DOSE-RESPONSE RELATIONSHIPS; HEPATOMAS; LIVER; PATIENTS; RADIATION DOSES; RADIOSENSITIVITY; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SULFUR; TECHNETIUM 99
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARCINOMAS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; DISPERSIONS; DOSES; ELEMENTS; EMISSION COMPUTED TOMOGRAPHY; GLANDS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NEOPLASMS; NONMETALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; SENSITIVITY; TECHNETIUM ISOTOPES; TOMOGRAPHY; YEARS LIVING RADIOISOTOPES

Optional Information

Copyright
Copyright (c) 2018 Elsevier Inc. All rights reserved.