Published July 1979 | Version v1
Journal article Metadata-only

GABA metabolism in the mouse brain after exposure of head to 60Co-γ-rays

Creators

  • 1. Odesskij Meditsinskij Inst. (Ukrainian SSR)

Description

A study was made of the content of gamma-aminobutyric acid (GABA), glutamate and the total of aspartate+asparagine+glutamine, and activity of glutamatedecarboxylase and GABA-α-ketoglutarate aminotransferase in the mouse brain after exposure of head to 1500 R of 60Co-γ-rays. GABA content gradually inc.reases shortly after exposure, and glutamate content decreases at later times following irradiation. The activity of both enzymes diminishes: in the case of GABA-transaminase, however, the diminution proceeded slower and lasted longer. The role of shifts in the GABA system in the development of damages to the nervous system after local exposure is discussed

Additional details

Additional titles

Original title (Russian)
Обмен гамк в головном мозге при облучении области головы γ-лучами

Publishing Information

Journal Title
Radiobiologiya
Journal Volume
19
Journal Issue
4
Series
Radiobiologiya.
Journal Page Range
532-536
ISSN
0033-8192

INIS

Country of Publication
Russian Federation
Country of Input or Organization
USSR
INIS RN
11510645
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Numerical Data
Descriptors DEI
ACUTE IRRADIATION; AMINOBUTYRIC ACID; BIOLOGICAL RADIATION EFFECTS; BRAIN; CATALYSIS; ENZYMES; EXPERIMENTAL DATA; GAMMA RADIATION; GRAPHS; HEAD; LOCAL IRRADIATION; MALES; METABOLISM; MICE; RADIATION DOSES; RADIATION SYNDROME
Descriptors DEC
AMINO ACIDS; ANIMALS; BIOLOGICAL EFFECTS; BODY; BODY AREAS; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; DATA; DATA FORMS; ELECTROMAGNETIC RADIATION; INFORMATION; IONIZING RADIATIONS; IRRADIATION; MAMMALS; NERVOUS SYSTEM; NUMERICAL DATA; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES

Optional Information

Notes
For English translation see the journal Radiobiology (USA).