Published June 14, 1982 | Version v1
Miscellaneous Open

Quantification of the regional brain blood flow rate and of the oxygen metabolism in a normal human: tomographic study with oxygen 15

Creators

Description

Whereas it is possible to qualitatively and quantitatively measure the blood flow rate, brain energy metabolism and their local correlations by using PET with various tracers, some data are accessible or not accessible for humans or for animals when using a continuous inhalation of oxygen-marked gases coupled with PET. This thesis aimed at proposing an approach to values of the regional brain blood flow rate and of the brain energy metabolism represented by the regional oxygen consumption, by using the method of continuous inhalation of gases marked with oxygen 15. It also reports the study of influencing factors. Values are discussed with respect to a theoretical model and to difficulties related to technical application. Reference normal values are proposed for individuals with a normal brain, and this allows the assessment of a focalized lesion. The flow rate/metabolism pair, and age effects on measured parameters are discussed

Abstract (French)

Ce travail a pour but de proposer une approche des valeurs de debit sanguin cerebral regional (DSCr) de consommation d'oxygene regionale (rCMRO2) par l'utilisation de la methode d'inhalation continue de gaz marques a l'oxygene 15, et l'etude des facteurs intervenant dans les resultats. Les valeurs de DSCr, de rCMRO2 et le taux d'extraction d'O2 (EO2) sont mesurees dans des regions d'interet placees au sein de zones cerebrales a dominance de substance grise ou blanche. Ces valeurs seront discutees en fonction des limites du modele theorique utilise et aussi des difficultes d'application technique. Des valeurs normales de reference seront proposees pour une serie de 19 sujets a cerveau normal, avec un intervalle de confiance a 95 %, ce qui permettra l'evaluation d'une lesion focalisee en pathologie. Le couple debit/metabolisme et les effets de l'age sur les parametres mesures seront aussi commentes. La technique d'inhalation continue d'oxygene 15 couplee a la tomographie d'emission de positons est actuellement la seule technique suffisamment validee qui permette d'etudier localement le DSCr et la rCMRO2 et cela de facon atraumatique. Ce travail permet d'etablir des donnees de reference pour l'etude des affections neuro-psychiatriques mais aussi de montrer que malgre la complexite de l'infrastructure exigee, la quantification est realisable de facon tout a fait satisfaisante par la methode 15O

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Additional details

Additional titles

Original title (French)
Quantification du debit sanguin cerebral regional et du metabolisme de l'oxygene chez l'homme normal: etude tomographique avec l'oxygene 15

Publishing Information

Imprint Pagination
81 p.
Report number
FRCEA-TH--16001

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
54020315
Subject category
S60: APPLIED LIFE SCIENCES; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Resource subtype / Literary indicator
Thesis
Descriptors DEI
AGE DEPENDENCE; BIOLOGICAL MARKERS; BLOOD CIRCULATION; BLOOD FLOW; BRAIN; COMPARATIVE EVALUATIONS; FLOW RATE; GENOME MUTATIONS; HEALTH HAZARDS; HUMAN POPULATIONS; METABOLISM; OXYGEN 15; PHYSIOLOGY; POSITRON COMPUTED TOMOGRAPHY; RESPIRATION
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; EMISSION COMPUTED TOMOGRAPHY; EVALUATION; EVEN-ODD NUCLEI; HAZARDS; ISOTOPES; LIGHT NUCLEI; MINUTES LIVING RADIOISOTOPES; MUTATIONS; NERVOUS SYSTEM; NUCLEI; ORGANS; OXYGEN ISOTOPES; POPULATIONS; RADIOISOTOPES; TOMOGRAPHY

Optional Information

Notes
71 refs.; Available from the INIS Liaison Officer for France, see the INIS website for current contact and E-mail addresses