Published 1985 | Version v1
Book Metadata-only

[123I] HIPDM as a brain perfusion indicator for SPECT

Creators

  • 1. National Inst. of Mental Health, Bethesda, MD (USA)
  • 2. Rome Univ. (Italy). Dept. of Neurological Sciences
  • 3. Milan Univ. (Italy). Inst. S. Raffaele

Description

The metabolism and kinetics of cerebral uptake of radioactive iodine labelled HIPDM were studied in vivo in rats to evaluate its potential usefulness for quantitative measurement of regional cerebral blood flow (rCBF). The results demonstrate that a method for quantitative measurement of rCBF with iodine labelled HIPDM must take into account its metabolic degradation, diffusion limitations, and bidirectional flux across the blood-brain barrier. Clinical studies have demonstrated that its intracerebral distribution, as assessed by single photon emission tomography (SPECT), reflects the distribution of rCBF. These observations suggest that this molecule might be of potential usefulness for quantitative rCBF measurement with SPECT. (author)

Additional details

Publishing Information

Publisher
John Libby and Company Limited.
Imprint Place
London (UK)
ISBN
0-86196-060-2
Imprint Title
New brain imaging techniques in cerebrovascular diseases
Imprint Pagination
135 p.
Journal Volume
2
Series
Current Problems in Neurology.
Journal Page Range
p. 47-53.

Conference

Title
4. Beaune international conference.
Dates
19-20 Oct 1984.
Place
Beaune (France).

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
18023134
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
AMINES; BLOOD FLOW; BRAIN; IN VIVO; IODINE 123; MAN; RADIOPHARMACEUTICALS; RATS; SINGLE PHOTON ECT; TISSUE DISTRIBUTION
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DISTRIBUTION; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PRIMATES; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; TOMOGRAPHY; VERTEBRATES