Radioiodination and biodistribution of NBNPQD ( 2-benzyl-1-oxo-1-2-dihydropyrido (4,3-b) quinoxaline 5,10- dioxide) in tumor bearing mice

NBNPQD (2-benzyl-1-oxo-1,2 dihydropyrido (quinoxaline 5,10-dioxide) is a new synthesized quinoxaline derivative. It could be labeled with Auger emitter iodine-125 successfully with yield about 90%. The labeled product was evaluated by electrophoresis and studied. 123I- NBNPQD was stable up to 48 h post labeling. Biodistribution study of 123I- NBNPQD in normal and tumor bearing mice was also conducted. The biodistribution data revealed that 123I-NBNPQD diffused rapidly to tumor sites in to both ascites and solid tumor bearing mice. 123I-NBNPQD was decline rapidly from most of organs but slowly from tumor sites. In-vitro radiotoxicity of 123I- NBNPQD increased with the increase of its radioactivity. This study encourages the possible use of 123I- NBNPQD in tumor imaging and treatment. It also encourages further studies on the chemotherapeutic activity of NBNPQD hoping to get a new potent antitumor agent. (Author)