Published April 1985 | Version v1
Journal article Metadata-only

Interactions between radiopharmaceuticals and therapeutic drugs

Creators

  • 1. Bundesgesundheitsamt, Neuherberg (Germany, F.R.). Inst. fuer Strahlenhygiene

Description

The effect of D-penicillamine on the distribution of sup(99m)Tc-MDP was studied in male Wistar rats. There were significant activity decreases after medication in blood, kidney, lung and skeletal muscle. The activity in the skeleton was not influenced by D-penicillamine. After treatment, the liver showed a significant increase of activity. The clearance of activity not bound to the skeleton altogether accelerates after D-penicillamin medication. It is assumed that the change of kinetics is caused by a complex formation of the radiopharmaceutical and D-penicillamine. D-penicillamine possibly displaces methylene diphosphonate from the sup(99m)Tc-complex. (orig.)

Abstract (German)

An maennlichen Wistar-Ratten wurde der Einfluss von D-Penicillamin auf die Verteilung von sup(99m)Tc-MDP untersucht. Es zeigten sich signifikante Verminderungen der Aktivitaetskonzentration nach der Medikation in Blut, Niere, Lunge und Skelettmuskulatur. Die Aktivitaetsanreicherung im Skelett wurde durch D-Penicillamin nicht beeinflusst. Die Leber zeigte nach der Medikation eine signifikante Aktivitaetserhoehung. Insgesamt ist die Clearance der nicht skelettgebundenen Aktivitaet nach D-Penicillamin beschleunigt. Es wird angenommen, dass eine Komplexbildung zwischen dem Radiopharmakon und D-Penicillamin die Ursache fuer diese Veraenderung der Kinetik ist. Moeglicherweise verdraengt D-Penicillamin das Methylendiphosphonat aus dem sup(99m)Tc-Komplex. (orig.)

Additional details

Additional titles

Subtitle (English)
The effect of D-penicillamine on the distribution of sup(99m)Tc-MDP
Original title (German)
Interaktionen zwischen Radiopharmaka und Therapeutika
Original subtitle (German)
Beeinflussung der Verteilung des sup(99m)Tc-Methylendiphosphonats durch D-Penicillamin.

Publishing Information

Journal Title
Nuklearmedizin
Journal Volume
24
Journal Issue
2
Series
CODEN: NUKLD.;Nuklearmedizin.
Journal Page Range
82-86
ISSN
0029-5566

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
16067587
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
COMPARATIVE EVALUATIONS; COMPLEXES; DISTRIBUTION; INTERACTIONS; ISOMERIC NUCLEI; PENICILLAMINE; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; RATS; TECHNETIUM COMPOUNDS; TECHNETIUM 99; TIME DEPENDENCE
Descriptors DEC
AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CHELATING AGENTS; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; TECHNETIUM ISOTOPES; THIOLS; TRANSITION ELEMENT COMPOUNDS; VERTEBRATES; YEARS LIVING RADIOISOTOPES