Published October 2009 | Version v1
Journal article Metadata-only

Imaging of regional metabolic activity by 18F-FDG/PET in rats with transient cerebral ischemia

Creators

  • 1. Department of Chemistry, Chung Yuan Christian University, Chung-Li, Taiwan (China)
  • 2. Institute of Nuclear Energy Research, Tao-Yuan, Taiwan (China)

Description

Changes in regional metabolic activities induced by middle cerebral artery occlusion (MCAO) can influence patient outcome. Our aim was to demonstrate in a rat model that 18F-FDG with positron emission tomography (PET) imaging is a quantitative, reproducible approach for identifying acute and sub-acute metabolic variations in infarct regions. We found that imaging with 18F-FDG/PET enabled detection and quantification of ischemia-induced metabolic deficits and provided a sensitive and reliable means of assessing cerebral ischemic lesions compared with conventional neurological scoring systems in rodents.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.apradiso.2009.03.002

Additional details

Identifiers

DOI
10.1016/j.apradiso.2009.03.002;
PII
S0969-8043(09)00219-X;

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
67
Journal Issue
10
Journal Page Range
p. 1743-1747
ISSN
0969-8043
CODEN
ARISEF

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
41014103
Subject category
S07: ISOTOPES AND RADIATION SOURCES;
Descriptors DEI
CEREBRAL ARTERIES; FLUORINE 18; ISCHEMIA; PATIENTS; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS
Descriptors DEC
ANEMIAS; ANIMALS; ARTERIES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BLOOD VESSELS; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HEMIC DISEASES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MATERIALS; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; SYMPTOMS; TOMOGRAPHY; VASCULAR DISEASES; VERTEBRATES

Optional Information

Copyright
Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.