Biokinetics and biological effects of inhaled plutonium in rats
Creators
- 1. National Inst. of Radiological Sciences, Chiba (Japan)
Description
The biokinetics and biological effects of inhaled plutonium oxide were studied in the rat. Aerosols of plutonium oxide were generated by nebulizing plutonium hydroxide and passing them through a high temperature furnace. Female rats were exposed to the aerosols using a nose only exposure chamber. The animals are being kept for observation of tumor induction. In vivo countings of plutonium in lung area of the rats revealed that retention curve can be described by an exponential equation and the retention was much higher than that reported by Sanders of PNL of USA. So far only one rat died spontaneously about 11 months after inhalation which showed precancerous lesion in the alveoli. (author)
Files
Restricted
The record is publicly accessible, but files are restricted to users with access.
Additional details
Publishing Information
- Imprint Title
- Proceedings of the international conference on radiation effects and protection
- Imprint Pagination
- 558 p.
- Journal Page Range
- p. 247-249.
- Report number
- INIS-JP--008
Conference
- Title
- International conference on radiation effects and protection.
- Dates
- 18-20 Mar 1992.
- Place
- Mito (Japan).
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 24061071
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; CARCINOGENESIS; HISTOLOGY; INHALATION; LUNGS; PLUTONIUM DIOXIDE; PLUTONIUM 239; RADIOACTIVE AEROSOLS; RADIONUCLIDE KINETICS; RATS; TIME DEPENDENCE
- Descriptors DEC
- ACTINIDE COMPOUNDS; ACTINIDE NUCLEI; AEROSOLS; ALPHA DECAY RADIOISOTOPES; ANIMALS; BIOLOGICAL EFFECTS; BODY; CHALCOGENIDES; COLLOIDS; DISPERSIONS; EVEN-ODD NUCLEI; HEAVY NUCLEI; INTAKE; ISOTOPES; KINETICS; MAMMALS; NUCLEI; ORGANS; OXIDES; OXYGEN COMPOUNDS; PATHOGENESIS; PLUTONIUM COMPOUNDS; PLUTONIUM ISOTOPES; PLUTONIUM OXIDES; RADIATION EFFECTS; RADIOISOTOPES; RESPIRATORY SYSTEM; RODENTS; SOLS; SPONTANEOUS FISSION RADIOISOTO; TRANSURANIUM COMPOUNDS; VERTEBRATES; YEARS LIVING RADIOISOTOPES