Published August 2018 | Version v1
Journal article Metadata-only

Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole

Creators

  • 1. University of Manchester, Manchester (United Kingdom). Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health
  • 2. Wolfson Molecular Imaging Centre, University of Manchester, Manchester (United Kingdom)
  • 3. Universite d'Auvergne, 63 - Clermont-Ferrand (France). Faculte de Pharmacie
  • 4. University of Cambridge, Cambridge (United Kingdom). Wolfson Brain Imaging Centre, Department of Clinical Neurosciences

Description

N-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of N-[11C]methyl carbamoylimidazole as a new [11C]synthon to radiolabel biomolecules for PET imaging research. N-[11C]methyl carbamoylimidazole was prepared from [11C]methyl iodide in 70-74% radiochemical yield (decay corrected) and can be used in situ for further reaction without purification. The reactivity of N-[11C]methyl carbamoylimidazole was demonstrated in a series of [11C]carbamoylation reactions. (author)

Additional details

Publishing Information

Journal Title
Journal of Radioanalytical and Nuclear Chemistry
Journal Volume
317
Journal Issue
2
Journal Page Range
p. 977-984
ISSN
0236-5731
CODEN
JRNCDM

INIS

Country of Publication
Hungary
Country of Input or Organization
Hungary
INIS RN
49085407
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
ISOCYANATES; LABELLING; METHYL IODIDE; POSITRON COMPUTED TOMOGRAPHY; RADIOCHEMISTRY; RADIOPHARMACEUTICALS; SYNTHESIS
Descriptors DEC
CARBONIC ACID DERIVATIVES; CHEMISTRY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; HALOGENATED ALIPHATIC HYDROCARBONS; IODINATED ALIPHATIC HYDROCARBONS; LABELLED COMPOUNDS; MATERIALS; NITROGEN COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; RADIOACTIVE MATERIALS; TOMOGRAPHY

Optional Information

Notes
17 refs.