Published October 1982
| Version v1
Journal article
Synthesis of ''no carrier added'' 1,3-bis-(2-chloroethyl)nitrosourea (BCNU)
- 1. McGill University, Montreal, Quebec, Canada
Description
A chemotherapeutic agent, C-11-labeled BCNU, has been prepared by nitrosation of C-11-labeled BCU, which was synthesized by reacting C-11-labeled phosgene with ethylenimine. Two methods of nitrosation are outlined and the results of both are discussed. The specific activity of C-11 BCNU was about 85 Ci/mmole at the end of bombardment and 30 Ci/mmole at the time of administration. Chemical and radiochemical purity of the final material was at least 98%
Additional details
Publishing Information
- Journal Title
- J. Nucl. Med.
- Journal Volume
- 23
- Journal Issue
- 10
- Series
- J. Nucl. Med.
- Journal Page Range
- 895-898
- ISSN
- 0022-3123
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 14749205
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CARBON 11; CHEMICAL PREPARATION; LABELLING; NITROSO COMPOUNDS; RADIOCHEMISTRY; RADIOPHARMACEUTICALS
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CHEMISTRY; DRUGS; EVEN-ODD NUCLEI; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS