Published February 2008
| Version v1
Journal article
Investigations to the synthesis of n.c.a. [18F]FClO3 as electrophilic fluorinating agent
- 1. Institute of Interdisciplinary Isotope Research, Permoserstrasse 15, D-04318 Leipzig (Germany)
- 2. Department for Nuclear Medicine, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, D-93053 Regensburg (Germany)
- 3. Institute of Radiopharmacy, Research Centre Dresden-Rossendorf, D-01314 Dresden (Germany)
Description
An approach to synthesize the electrophilic fluorinating agent no-carrier-added (n.c.a.) [18F]perchloryl fluoride ([18F]FClO3) in superacidic media in the presence of KClO4 or anhydrous perchloric acid starting from [18F]fluoride was demonstrated in this study. However, the radiochemical yields were low (1-6%) and poorly reproducible. Fluorosulphonic acid proved to be an essential intermediate as revealed by non-radioactive experiments. A key problem in the preparation of [18F]FClO3 is the assumed kinetic inhibition due to the unfavourable stoichiometric ratio of the ClO4 moiety to [18F]HSO3F
Availability note (English)
Available from http://dx.doi.org/10.1016/j.apradiso.2007.08.016Additional details
Identifiers
- DOI
- 10.1016/j.apradiso.2007.08.016;
- PII
- S0969-8043(07)00274-6;
Publishing Information
- Journal Title
- Applied Radiation and Isotopes
- Journal Volume
- 66
- Journal Issue
- 2
- Journal Page Range
- p. 152-157
- ISSN
- 0969-8043
- CODEN
- ARISEF
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 39047878
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- FLUORIDES; FLUORINATION; FLUORINE 18; PERCHLORIC ACID; POTASSIUM PERCHLORATES; RADIOCHEMISTRY; SYNTHESIS
- Descriptors DEC
- ALKALI METAL COMPOUNDS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CHEMICAL REACTIONS; CHEMISTRY; CHLORINE COMPOUNDS; FLUORINE COMPOUNDS; FLUORINE ISOTOPES; HALIDES; HALOGEN COMPOUNDS; HALOGENATION; HOURS LIVING RADIOISOTOPES; HYDROGEN COMPOUNDS; INORGANIC ACIDS; INORGANIC COMPOUNDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; OXYGEN COMPOUNDS; PERCHLORATES; POTASSIUM COMPOUNDS; RADIOISOTOPES
Optional Information
- Copyright
- Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.