Published October 1, 2006
| Version v1
Journal article
Improvement of sensitivity of multisample biological immunoassay system using HTS SQUID and magnetic nanoparticles
Creators
- 1. Advanced Research Laboratory, Hitachi Ltd., 1-280, Higashi-Koigakubo, Kokubunji-shi, Tokyo 185-8601 (Japan)
- 2. Central Research Laboratory, Hitachi Ltd., Kokubunji-shi, Tokyo 185-8601 (Japan)
- 3. Department of Clinical Chemistry and Laboratory Medicine, Kyushu University, Fukuoka 812-8582 (Japan)
- 4. Plastic Products Division, INOAC Corporation, Nagoya 456-0054 (Japan)
- 5. Department of Marketing, Kyushu INOAC, Fukuoka 812-0013 (Japan)
- 6. Research Institute of Superconductor Science and Systems, Kyushu University, Fukuoka 812-8581 (Japan)
Description
Recently, we have developed a prototype magnetic immunoassay system using a high temperature superconductor (HTS) superconducting quantum interference device (SQUID) to investigate the performance and usability of the magnetic immunoassay. In this study, we improved the immunoassay system to heighten the sensitivity of the immunoassay measurement. To reduce the SQUID-to-sample distance, we introduced a structure to compensate for thermal shrinkage in the cryostat and reduce the warpage of the window. The shape of pickup coil was also optimized to improve the field sensitivity. After these improvements, the magnetic signal intensity from Fe3O4 nanoparticles became about two times stronger than that achieved by our original system
Additional details
Identifiers
- DOI
- 10.1016/j.physc.2006.06.019;
- PII
- S0921-4534(06)00615-0;
Publishing Information
- Journal Title
- Physica. C, Superconductivity
- Journal Volume
- 445-448
- Journal Page Range
- p. 975-978
- ISSN
- 0921-4534
- CODEN
- PHYCE6
Conference
- Title
- 18. international symposium on superconductivity
- Acronym
- ISS 2005
- Dates
- 24-25 Oct 2005
- Place
- Tsukuba (Japan)
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 38066801
- Subject category
- S75: CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- CRYOSTATS; FERRITES; HIGH-TC SUPERCONDUCTORS; IMMUNOASSAY; IRON OXIDES; MAGNETISM; NANOSTRUCTURES; PARTICLES; PERFORMANCE; SENSITIVITY; SIGNALS; SQUID DEVICES
- Descriptors DEC
- BIOASSAY; CHALCOGENIDES; CONTROL EQUIPMENT; ELECTRONIC EQUIPMENT; EQUIPMENT; FERRIMAGNETIC MATERIALS; FLUXMETERS; IRON COMPOUNDS; MAGNETIC MATERIALS; MATERIALS; MEASURING INSTRUMENTS; MICROWAVE EQUIPMENT; OXIDES; OXYGEN COMPOUNDS; SUPERCONDUCTING DEVICES; SUPERCONDUCTORS; THERMOSTATS; TRANSITION ELEMENT COMPOUNDS; TYPE-II SUPERCONDUCTORS
Optional Information
- Copyright
- Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.