Published December 2019
| Version v1
Book
Preclinical evaluation of 3, 3'-diselenodipropionic add (DSEPA) as an oral lung radioprotector
- 1. Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Mumbai (India)
- 2. Chemistry Division, Bhabha Atomic Research Centre, Mumbai (India)
Description
Radiation pneumonitis (RP), a morbid complication of thoracic radiotherapy compromises the treatment intensity resulting in poorer clinical outcomes of thoracic malignancies. Therapeutic options for RP are limited; steroids are commonly used for long durations (4 - 6 months) with its antecedent complications. Present study demonstrated that 3'-diselenodipropionic acid (DSePA) not only prevents but also delays the onset and in some cases, reverses the severity of RP in mouse models by suppressing the NF-kB/IL-17jG-CSF/neutrophil axis. (author)
Additional details
Publishing Information
- Publisher
- Bhabha Atomic Research Centre
- Imprint Place
- Mumbai (India)
- ISBN
- 978-81-940321-5-1
- Imprint Title
- Proceedings of the fifteenth DAE-BRNS biennial Trombay symposium on radiation and photochemistry: book of abstract
- Imprint Pagination
- 184 p.
- Journal Page Range
- p. 46
Conference
- Title
- 15. DAE-BRNS biennial Trombay symposium on radiation and photochemistry
- Acronym
- TSRP-2020
- Dates
- 5-9 Jan 2020
- Place
- Mumbai (India)
INIS
- Country of Publication
- India
- Country of Input or Organization
- India
- INIS RN
- 54095187
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- CLINICAL TRIALS; LUNGS; PNEUMONITIS; RADIOPROTECTIVE SUBSTANCES; RADIOTHERAPY
- Descriptors DEC
- BODY; DRUGS; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; RESPIRATORY SYSTEM; RESPONSE MODIFYING FACTORS; TESTING; THERAPY