A repair ploidy model (RPM) for cell survival after irradiation

The Repair Ploidy Model (RPM) attempts to provide a theory for cell survival after irradiation which accounts explicitly for the kinetics of correct repair and repair induced chromosomal aberrations and thus includes time as a variable. Additionally, cell ploidy is a parameter in the model which accounts for differences in radiation response between haploid, diploid and higher ploidy cells. The ploidy parameter is related to the target concentration and redundancy of genetic information. The RPM model describes two mechanisms which contribute to cellular loss of survival; namely the generation of chromosomal deletions with linear dose behavior and the generation of critical chromosomal aberrations with quadratic dose behavior. The model is derived strictly from biological mechanisms and contains only measurable variables