Published May 2016 | Version v1
Journal article Metadata-only

Synthesis by pulsed laser ablation of 2D nanostructures for advanced biomedical sensing

Creators

  • 1. CNR-IPCF, Istituto per i Processi Chimico-Fisici del CNR, V.le. F. S. D'Alcontres 37, 98158 Messina (Italy)
  • 2. Dipartimento di Energia, Politecnico di Milano, Via Ponzio 34/3, 20133 Milano (Italy)
  • 3. Dipartimento di Chimica, Materiali e Ingegneria Chimica 'Giulio Natta', Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)
  • 4. Laboratorio di Patologia Clinica e Genetica Medica, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano (Italy)
  • 5. Unità Operativa Neurologia 1—Disturbi del Movimento, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano (Italy)

Description

Au nanoparticle arrays with controlled nanostructure were produced by pulsed laser ablation on glass. Such substrates were optimized for biomedical sensing by means of SERS keeping fixed all process parameters but the laser pulse (LP) number that is a key deposition parameter. It allows to fine-tune the Au surface nanostructure with a considerable improvement in the SERS response towards the detection of apomorphine in blood serum (3.3 × 10−6 M), when LP number is increased from 1 × 104 to 2 × 104. This result is the starting point to correlate the intensity of selected SERS signals of apomorphine to its concentration in the blood of patients with Parkinson's disease.

Availability note (English)

Available from http://dx.doi.org/10.1088/1748-0221/11/05/C05006

Additional details

Identifiers

DOI
10.1088/1748-0221/11/05/C05006;

Publishing Information

Journal Title
Journal of Instrumentation
Journal Volume
11
Journal Issue
05
Journal Page Range
p. C05006
ISSN
1748-0221

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
49000973
Subject category
S46: INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY;
Descriptors DEI
ABLATION; BIOMEDICAL RADIOGRAPHY; BLOOD SERUM; CONCENTRATION RATIO; DEPOSITION; GLASS; GOLD; LASER RADIATION; LASERS; NANOPARTICLES; NANOSTRUCTURES; PULSES; SIGNALS; SUBSTRATES; SYNTHESIS; TWO-DIMENSIONAL CALCULATIONS
Descriptors DEC
BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY FLUIDS; DIAGNOSTIC TECHNIQUES; DIMENSIONLESS NUMBERS; ELECTROMAGNETIC RADIATION; ELEMENTS; MATERIALS; MEDICINE; METALS; NUCLEAR MEDICINE; PARTICLES; RADIATIONS; RADIOLOGY; TRANSITION ELEMENTS