Changes of drug transporter gene expression in radiation accidental exposed persons

To study the changes in delayed drug transporter gene expression induced by ionizing radiation, the differential expression of drug transporter genes in the peripheral blood of three people exposed accidentally to ⁶⁰Co γ-rays during 3 a after irradiation were analyzed using the Agilent whole genome gene expression microarray assay. The differentially expressed solute transporters (SLC) genes were studied. It was found that the genes of organic ion transporters and carbohydrate transporters were mainly up-regulated, while those of the other transporters were mainly down-regulated. There was no obvious up regulation and down regulation in the expression of amino acid/amine transporters and inorganic ion transporter genes. The differentially expressed genes of ATP-binding cassette transporter (ABC) found that ABC transporter genes expression was mainly focused on multi-drug resistance transporter genes. The gene expression profiles of multiple drug transporters were altered in the three people who were accidentally exposed to radiation. Some clinical drugs that they were administered are substrates of these drug transporters, may change the pharmacokinetic profiles of these drugs. These data also provided a reference for studying the effects of ionizing radiation on drug absorption, distribution, and excretion. (authors)