Comparison between manual labelling of ⁶⁸GA-DOTANOC with ITG AND ITHEMBA GENERATOR: a preliminary study

Gallium-68 DOTANOC binds to the somatostatin receptors that are seen on the surface of Neuro endocrine tumour. By injecting the tracer into patients, PET-CT scans can be done to visualize the tumours. There are two methods of labelling DOTANOC. The manual and the generator based methods are commonly used to label the DOTANOC with ⁶⁸Ga. To compare the manual labelling of ⁶⁸Ga-DOTANOC with ITG and ithemba generator types. Average radiochemical purity of manual labelling of ITG generator and ithemba generator were 96.02 ± 0.54 % and 97.81 ± 0.32 % respectively. There is no statistical difference between radiochemical purity of manual labelling and two generator types (p > 0.05). Our study suggests that there was no significance difference between radiochemical purity of manual labelling and two generator types. Moreover ithemba generator gives better radiochemical purity