Published 1998 | Version v1
Report Open

Oxygen effect and influence of the anoxic radiosensitizing agent TAN on the induction of λ-prophage in polA and wild type E.coli strains after gamma irradiation

Creators

  • 1. Division of Radiation and Radiobiological Research, Joint Institute for Nuclear Research, Dubna (Russian Federation)
  • 2. Institute for Nuclear Research and Nuclear Energy, Sofia (Bulgaria)

Description

The modification effect of both oxygen and radiosensitizing agent TAN on the λ-prophage induction in polA mutant and wild type E.coli cells after γ-irradiation was studied. The oxygen and TAN enhancement ratio concerning the cell sensitivity is more significant in polA mutant cells as compared to that in the wild type ones. The same behaviour has been observed for the oxygen and TAN enhancement ratio for the λ-prophage induction. The TAN effect on the survival and on the λ-induction was smaller than the oxygen effect. The bigger efficiency of oxygen and DNA-radicals are more difficult to repair than those created by an interaction of TAN and DNA-radicals

Availability note (English)

Available from INIS in electronic form

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Additional details

Publishing Information

Imprint Pagination
12 p.
Report number
JINR-E--19-98-2

INIS

Country of Publication
Joint Institute for Nuclear Research (JINR)
Country of Input or Organization
Joint Institute for Nuclear Research (JINR)
INIS RN
29053591
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ANOXIA; BACTERIOPHAGES; BIOLOGICAL RADIATION EFFECTS; ESCHERICHIA COLI; GAMMA RADIATION; OXYGEN; RADIATION INDUCED MUTANTS; RADIOSENSITIVITY; SURVIVAL CURVES; TRIACETONEAMINE-N-OXYL
Descriptors DEC
AMINES; AZINES; BACTERIA; BIOLOGICAL EFFECTS; DRUGS; ELECTROMAGNETIC RADIATION; ELEMENTS; HETEROCYCLIC COMPOUNDS; IONIZING RADIATIONS; KETONES; MICROORGANISMS; MUTANTS; NONMETALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PARASITES; PIPERIDINES; PYRIDINES; RADIATION EFFECTS; RADIATIONS; RADIOSENSITIZERS; RESPONSE MODIFYING FACTORS; VIRUSES

Optional Information

Notes
8 refs., 4 figs., 1 tab.