Published January 1984
| Version v1
Journal article
Modified human fibrinogen labeled with 111In
Creators
- 1. Israel Atomic Energy Commission, Yavne. Soreq Nuclear Research Center
Description
A method for the labeling of human fibrinogen with 111In is reported. The cyclic anhydride of DTPA, either dissolved in dimethyl sulfoxide or as the solid, is first covalently attached to the protein. The modified fibrinogen is then labeled with [111In]acetate, with an average yield of 90 +- 3%. The product obtained is highly clottable and stable in vitro and has potential applications in imaging studies. (author)
Additional details
Publishing Information
- Journal Title
- Int. J. Appl. Radiat. Isot.
- Journal Volume
- 35
- Journal Issue
- 1
- Series
- Int. J. Appl. Radiat. Isot.
- Journal Page Range
- 69-70
- ISSN
- 0020-708X
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 15030380
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ACETATES; ANHYDRIDES; CHEMICAL PREPARATION; CHROMATOGRAPHY; DMSO; DTPA; FIBRINOGEN; IMAGES; INDIUM 111; LABELLED COMPOUNDS; MAN
- Descriptors DEC
- AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BLOOD COAGULATION FACTORS; CARBOXYLIC ACID SALTS; CARBOXYLIC ACIDS; CHELATING AGENTS; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; GLOBULINS; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PRIMATES; PROTEINS; RADIOISOTOPES; SEPARATION PROCESSES; SULFOXIDES; SYNTHESIS; VERTEBRATES