Heart Rate Variability In Obese Endometrial Cancer Patients

Purpose of the study. To reveal peculiarities of autonomic regulation, determined by heart rate variability (HRV) indices, in endometrial cancer patients with different degrees of obesity. Materials and Methods. The study enrolled 63 patients with stages I–II endometrial cancer (EC) (T1a-bN0M0– T2a-bN0M0) who had undergone total hysterectomy. The study of HRV was performed using the Spectrum + diagnostic complex. HRV was analyzed by means of methods of temporal and spectral analysis and the variation pulsometry method. Indicators of HRV were analyzed in groups of patients who differed by body mass index. Results. In patients with obesity, a decrease in HRV was recorded. The total signal power of vegetative influences in the group with normal weight was 1561 ms² . In groups with I, II and III degrees of obesity, this indicator was 1202 ms² , 998 ms² and 432 ms² , respectively. The lowest rates of temporal and spectral analysis of HRV were recorded in patients with degree III obesity. These patients also had a high stress index of regulatory systems. Correlations between body mass index and HRV indices have been established. Conclusion. In endometrial cancer patients with obesity, a decrease in HRV was observed, which indicates the prevalence of sympathetic influences in these patients. The degree of disturbance of vegetative influences is directly dependent on the degree of obesity. Lifestyle changes aimed at normalizing body weight can be recommended to prevent disturbances of autonomic regulation and reduce the risk of endometrial cancer.