Evaluation of area at risk by 123I-BMIPP in patients with acute myocardial infarction

The purpose of this study was to investigate the detection of area at risk of acute myocardial infarction (AMI) by 123I-BMIPP (BMIPP). 99mTc-tetrofosmin (TF) scintigraphy was performed on 13 patients with AMI with total coronary occlusion. BMIPP scintigraphy was done on the same patients within 1 week after successful reperfusion by direct PTCA. Activity of both tracers was scored in 8 basal, 8 midventricular and 2 apical segments, using a four-point grading system as defect score: 3=defect, 2=severely low uptake, 1=slightly low uptake, 0=normal. Extent score (ES) was defined as a total number of segment which deteriorated uptake, and severity score (SS) was defined as a total score of defect score. ES of BMIPP was 6.5±2.4 and that of TF was 7.5±2.4. ES of BMIPP was smaller than that of TF. A ratio of BMIPP/TF was 0.86±0.18. SS of BMIPP was 16.2±6.0 and that of TF was 19.2±5.6. SS of TF was larger than that of BMIPP. A ratio of BMIPP/TF was 0.83±0.18. A correlation of ES and SS between TF and BMIPP was excellent. BMIPP showed ischemic area by culprit lesion and infarct area clearly. We concluded that BMIPP could indicate area at risk. (author)