Published November 1981
| Version v1
Journal article
Inhibition of hybrid resistance to lymphomas by inactivated tumor cells in lethally irradiated mice
Description
Two murine lymphomas, L5MF-22 of B10.129(5M) (H-2/sup b/) origin and P388 of DBA/2 (H-2/sup d/) origin, were inoculated into lethally irradiated hybrid (C57BL/6 x DBA/2)F1 (B6D2F1) mice (H-2/sup b//H-2/sup d/). Marked localized graft resistance was found in the spleen and occasionally in the liver of recipient mice as a result of a non-T-dependent hybrid resistance (HR). Significant reduction of HR of B6D2F1 mice could be obtained when viable lymphoma cells were inoculated along with inactivated cells of the same tumor or of genetically related leukemias. These results suggest that in vivo competition for HR effectors can take place in mouse spleen and liver leading to a depression of the localized resistance
Additional details
Publishing Information
- Journal Title
- Transplantation
- Journal Volume
- 32
- Journal Issue
- 5
- Series
- Transplantation.
- Journal Page Range
- 355-362
- ISSN
- 0041-1337
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 13683747
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- BIOLOGICAL EFFECTS; CELL PROLIFERATION; EXPERIMENTAL DATA; GENETIC CONTROL; IMMUNE REACTIONS; INACTIVATION; INHIBITION; LEUKEMIA; LIVER; LYMPHOMAS; MICE; RADIATION CHIMERAS; SPLEEN; TUMOR CELLS
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BODY; CHIMERAS; DATA; DIGESTIVE SYSTEM; DISEASES; GLANDS; HEMIC DISEASES; INFORMATION; MAMMALS; MOSAICISM; NEOPLASMS; NUMERICAL DATA; ORGANS; PEST CONTROL; RODENTS; VERTEBRATES