Decreased uptake of GABA by dorsal ganglia in methylmercury-treated rats
Creators
- 1. Niigata Univ., Brain Research Inst., Japan
Description
The uptake of 14C-GABA and 14C-choline by cerebral cortex slices did not show any change in rats which showed neurological signs 7 days after the last 7 methylmercury injections (10 mg/kg/day). However, 14C-GABA uptake by dorsal ganglia greatly decreased, although 14C-choline uptake did not decrease in dorsal ganglia. 14C-GABA uptake by cerebellum also was somewhat decreased. The degree of inhibition of 14C-GABA uptake by dorsal ganglia increased each day after the commencement of methylmercury injection. The decrease of 3H-GABA uptake by dorsal ganglia of methylmercury-injected rats was confirmed by autoradiography. Autoradiographic and inhibitor studies showed labelled GABA accumulated in the satellite glial cells. In vitro addition of methylmercury (10(-4)-10(-5) M) equally inhibited the uptake of GABA and choline by brain and dorsal ganglia slices. These studies may reveal a possible mechanism of methylmercury neuropathy
Additional details
Publishing Information
- Journal Title
- Neurotoxicology (Park Forest South, Ill.)
- Journal Volume
- 2
- Journal Issue
- 3
- Series
- Neurotoxicology (Park Forest South, Ill.).
- Journal Page Range
- 557-566
- ISSN
- 0161-813X
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 14749935
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- AMINES; AUTORADIOGRAPHY; BIOLOGICAL EFFECTS; CARBON 14 COMPOUNDS; CEREBELLUM; CEREBRUM; CHOLINE; GANGLIONS; INHIBITION; METABOLISM; ORGANIC MERCURY COMPOUNDS; RATS; RETENTION; UPTAKE
- Descriptors DEC
- ALCOHOLS; ANIMALS; BODY; BRAIN; CARBON COMPOUNDS; CENTRAL NERVOUS SYSTEM; HYDROXY COMPOUNDS; LIPOTROPIC FACTORS; MAMMALS; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANS; QUATERNARY COMPOUNDS; RODENTS; VERTEBRATES