Published February 1992 | Version v1
Journal article Metadata-only

Further investigation on the radiosynthesis of α-[11C]methyl-tryptophan

Creators

  • 1. Johns Hopkins Medical Institutions, Baltimore, MD (United States)

Description

Improved procedures for the radiosynthesis of α-[11C]-methyl-tryptophan and α-[11C]methyl-tryptophan methyl ester were studied. Following α-deprotonation of tryptophan methyl ester benzaldimine with LDA, 60 - 80% of no carrier added [11C]iodomethane was incorporated in 5 minutes at 27 - 30 oC. After HPLC purification, radiochemically pure α-[11C]methyl-tryptophan or its methyl ester was produced with minimum chemical contamination form tryptophan. The [11C]methyl-tryptophan synthesized, however, was found to be a racemate. (Author)

Additional details

Publishing Information

Journal Title
Journal of Labelled Compounds and Radiopharmaceuticals
Journal Volume
31
Journal Issue
2
Journal Page Range
p. 151-157.
ISSN
0362-4803
CODEN
JLCRD4

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
24000230
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
CARBON 11; CHEMICAL PREPARATION; LABELLING; RADIOPHARMACEUTICALS; TRYPTOPHAN
Descriptors DEC
AMINO ACIDS; AZOLES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CARBOXYLIC ACIDS; DRUGS; EVEN-ODD NUCLEI; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; INDOLES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRROLES; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS

Optional Information

Contract/Grant/Project number
Grant USPHS DA 06309; USPHS NS-15080