Annual report on long-term dose-response studies of inhaled or injected radionuclides, October 1, 1988--September 30, 1989

Since 1967, it has been customary for the staff of the Inhalation Toxicology Research Institute (ITRI) to publish an annual report presenting highlights of the past year's research accomplishments. In each annual report up to the present year, a substantial amount of information was presented on the status of the life-span studies of dogs that inhaled different alpha- or beta-emitting radionuclides. This information was presented as topical research reports, status reports on each study and appendices containing dose and response data for individual dogs in each study. Collectively, these reports provide a valuable history of each study and the general observations that have been made to date. When plans were made for the 1988--1989 ITRI Annual Report, it was decided to publish all information on these life-span studies in a separate periodic report. This report, which is the first to deal with these lifespan studies separately, is designed to have stand-alone informational content regarding current data and also to provide references to past annual reports. It is anticipated that this report will be published annually and maintain the flow of study-related information that has been a hallmark of previous ITRI Annual Reports. This report presents detailed information on both the ITRI and University of Utah radionuclide toxicity studies of dogs. The incorporation of annual information on the Utah-initiated studies reflects the current ITRI/Utah relationship established by DOE/OHER for completion of these studies. 53 figs., 47 tabs