Published February 15, 2019 | Version v1
Journal article Metadata-only

Prognostic significance of neutrophil/lymphocyte ratio (NLR) and correlation with PET–CT metabolic parameters in small cell lung cancer (SCLC)

Creators

  • 1. Çukurova University Faculty of Medicine, Department of Medical Oncology (Turkey)
  • 2. Çukurova University Faculty of Medicine, Department of Nuclear Medicine (Turkey)
  • 3. Çukurova University Faculty of Medicine, Department of Biostatistics (Turkey)
  • 4. Çukurova University Faculty of Medicine, Department of Internal Medicine (Turkey)

Description

Purpose

The aim of this study is to detect the prognostic significance of neutrophil/lymphocyte ratio (NLR) in SCLC and to evaluate the relation with 18F-FDG PET–CT metabolic parameters (PET–CT MPs).

Methods

Demographic parameters, laboratory values including NLR and other clinical variables were analyzed in 112 patients with small cell lung cancer (SCLC) and 54 of these patients had results of metabolic parameters detected with 18 FDG PET–CT [including SUVmax, SUVmean, metabolic tumor volume (MTV), whole body MTV (WBMTV), TLG (total lesion glycolysis), whole body TLG (WBTLG)] were evaluated for survival analyses.

Results

Mean and median overall survival (OS) and progression-free survival (PFS) were found to be significantly longer in cases with NLR < 4 compared with NLR > 4 in totally. Also stage, performance status, response to first-line therapy, LDH, and lymphocyte count were found to be prognostic for OS and PFS. MTV, WBMTV and WBTLG were found to be prognostic for both OS and PFS, while SUVmax found to be significant for OS. Patients with NLR ≥ 4, MTV ≥ 60.1, WBMTV ≥ 120 and WBTLG ≥ 1000 points had lower OS and PFS. A moderate positive correlation was found between NLR and SUVmean (r: 0.36), SUVmax (r: 0.34), TLG (r: 0.39), MTV (r: 0.51), WBMTV (r: 0.40), and WBTLG (r: 0.46).

Conclusion

There is relationship between PET–CT metabolic parameters and NLR in SCLC. Highest correlation was found with NLR and MTV, WBMTV, and WBTLG, and evaluation of NLR together with these parameters predicts survival times and tumor biology more clearly in SCLC.

Additional details

Identifiers

DOI
10.1007/s10147-018-1338-8;

Publishing Information

Journal Title
International Journal of Clinical Oncology
Journal Volume
24
Journal Issue
2
Journal Page Range
p. 168-178
ISSN
1341-9625

INIS

Country of Publication
Japan
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
54122191
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
FLUORINE 18; GLYCOLYSIS; LUNGS; LYMPHOCYTES; NEOPLASMS; NEUTROPHILS; PATIENTS; POSITRON COMPUTED TOMOGRAPHY; THERAPY
Descriptors DEC
ANIMAL CELLS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CHEMICAL REACTIONS; COMPUTERIZED TOMOGRAPHY; CONNECTIVE TISSUE CELLS; DECOMPOSITION; DIAGNOSTIC TECHNIQUES; DISEASES; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LEUKOCYTES; LIGHT NUCLEI; MATERIALS; MEDICINE; METABOLISM; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIOISOTOPES; RESPIRATORY SYSTEM; SOMATIC CELLS; TOMOGRAPHY

Optional Information

Copyright
Copyright (c) 2019 Japan Society of Clinical Oncology