Evaluation of the clinical validity of the ''integral spleen'' method of renography analysis from parameter changes induced by pharmacological and surgical intervention

A set of controlled experimental animal procedures involving pharmacological and surgical interventions was carried out to assess the clinical validity of the parameters calculated by the integral spleen method of renography analysis. There appeared to be a good correlation between the observed changes of these parameters and current pathophysiological information. In particular, the described method includes an original calculation of the filtration fraction without blood and urine sampling or a second tracer injection. This calculation was experimentally validated here