Published January 1977
| Version v1
Journal article
Synthesis of methyl iodide-11C and formaldehyde-11C
Creators
- 1. CEA, 91 - Orsay (France). Service Hospitalier Frederic Joliot
Description
A fast two-stage method of preparing formaldehyde-11C and methyl iodide-11C is described. 11CO2 is reduced to methanol-11C by LiAlH4 in THF, this product leading to formaldehyde-11C by oxidation on a silver catalyst, or to methyl iodide-11C by reaction with hydriodic acid. By means of these two molecules it is easy to methylate certain chemical groups and the method has been used to label substances of biological interest for research in vivo. The specific activity at the moment of use is 20 to 30 mCi/μmole, which indicates a high isotopic dilution. (author)
Additional details
Identifiers
Publishing Information
- Journal Title
- The International Journal of Applied Radiation and Isotopes
- Journal Volume
- 28
- Journal Issue
- 1-2
- Series
- Int. J. Appl. Radiat. Isot.
- Journal Page Range
- 49-52
- ISSN
- 0020-708X
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 8320784
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CARBON 11; CHEMICAL PREPARATION; CHEMICAL REACTION YIELD; FORMALDEHYDE; LABELLING; METHYL IODIDE; NUCLEAR MEDICINE; RADIOPHARMACEUTICALS
- Descriptors DEC
- ALDEHYDES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; DRUGS; EVEN-ODD NUCLEI; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MEDICINE; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS
Optional Information
- Notes
- Updated automatically by Metadata and Full-Text Enrichment Agent