Biological in vivo dosimetry with an external measuring technique under application of a labelled DNA-precursor (iodine-125-desoxyuridine)
- 1. Kernforschungsanlage Juelich G.m.b.H. (Germany, F.R.). Inst. fuer Medizin
Description
The depression of the incorporation rate of IDU in the whole body or in the bone marrow is a sensitive indicator for a whole-body irradiation. It was found that the maximum effect is observed some 4 hours after irradiation. For this reason, bone marrow cells were labelled in vitro with IDU 4 hours after whole-body irradiation. This method proved to be extraordinarily sensitive and resulted in reproducible effects which occurred already at doses below 5 rad. All the other biological methods of dosimetry known so far are less sensitive. Although the theory explaining these results is not yet fully clarified, this method of dosimetry appears to offer practical possibilities of application. (orig.)
Availability note (English)
MF available from INIS under the Report Number.Abstract (German)
Die Depression der Einbaurate von Joddesoxyuridin im Ganzkoerper bzw. im Knochenmark ist ein empfindlicher Indikator fuer eine Ganzkoerperbestrahlung. Es wurde festgestellt, dass der maximale Effekt etwa 4 Stunden nach der Bestrahlung auftritt. Daher wurden 4 Stunden nach der Ganzkoerperbestrahlung Knochenmarkzellen im Reagenzglas mit IDU markiert. Dieses Verfahren zeigte eine ausserordentliche Empfindlichkeit und resultierte in reproduzierbaren Effekten, welche bereits bei Dosen unterhalb von 5 Rad auftraten. Alle bisherigen biologischen Dosimetrie-Verfahren haben eine kleinere Empfindlichkeit. Obwohl die Theorie fuer diese Ergebnisse noch unklar ist, verspricht dieser Weg der Dosimetrie praktische Anwendungsmoeglichkeiten. (orig.)
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Additional details
Additional titles
- Original title (German)
- Biologische in vivo Dosimetrie mit einer externen Messtechnik unter Verwendung eines markierten DNA-Vorlaeufers (Jod-125-Desoxyuridin)
Publishing Information
- Imprint Pagination
- 4 p.
- Report number
- AED-Conf--76-530-003
Conference
- Title
- Annual meeting of the Deutsche Gesellschaft fuer Biophysik e.V.
- Dates
- 4 Oct 1976.
- Place
- Regensburg, Germany, F.R.
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 8306213
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S61: RADIATION PROTECTION AND DOSIMETRY;
- Resource subtype / Literary indicator
- Conference
- Is Lead record
- Yes
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; CELL CYCLE; DNA; DOSIMETRY; GAMMA RADIATION; HALF-LIFE; IODINE 125; MICE; MOLECULAR BIOLOGY; RADIATION DOSES; RADIOSENSITIVITY; TIME DEPENDENCE; URIDINE; WHOLE-BODY IRRADIATION
- Descriptors DEC
- ANIMALS; AZINES; BETA DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; DAYS LIVING RADIOISOTOPES; ELECTROMAGNETIC RADIATION; ELECTRON CAPTURE RADIOISOTOPES; EXTERNAL IRRADIATION; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; IONIZING RADIATIONS; IRRADIATION; ISOTOPES; MAMMALS; NUCLEI; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RIBOSIDES; RODENTS; URACILS; VERTEBRATES
Optional Information
- Notes
- 3 figs.; 15 refs.