Synthesis and radiolabelling-facilitated by Cu (1) of Para-Iodoamphetamine (PIPA): A radiopharmaceutical for brain perfusion imaging
Creators
- 1. Radiochemical Department, Renewable Energies and Water Desalination Research center, P. O. Box 30878 Tajoura, Tripoli (Libyan Arab Jamahiriya)
Description
The ultimate purpose of this paper is to develop a method for routine production of Para-Iodoamphetamine (PIPA) from phenamine, which is produced formerly through Leukart-Wallach reaction and elemental iodine by an electrophilic iodination reaction. Verification of the final product as indeed P-IPA is performed using melting point, IR spectroscopy, GC chromatography, and NMR spectroscopy. Production of high quality P-IPA labeled with radioactive 131I by Isotopic Exchange Reaction facilitated by Cu (1) generated ,In situ, is described in this paper. This type of radiopharmaceutical is produced to develop a tracer which could be taken up by the brain. [131I]-PIPA is obtained with radiochemical yield greater than 85% radiochemical purity of final product [131I]-PIPA is assessed by use of paper chromatography with high resolution. (author)
Additional details
Publishing Information
- Journal Title
- Al-Nawah
- Journal Volume
- 6
- Journal Issue
- 7
- Journal Page Range
- p. 3-19
- ISSN
- 2071-047X
INIS
- Country of Publication
- Libya
- Country of Input or Organization
- Libya
- INIS RN
- 40041621
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- BLOOD FLOW; BRAIN; CHEMICAL REACTION YIELD; COPPER; EXPERIMENTAL DATA; GAS CHROMATOGRAPHY; INFRARED SPECTRA; IODINE 131; ISOTOPIC EXCHANGE; NUCLEAR MAGNETIC RESONANCE; RADIOPHARMACEUTICALS
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; CHROMATOGRAPHY; DATA; DAYS LIVING RADIOISOTOPES; DRUGS; ELEMENTS; INFORMATION; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAGNETIC RESONANCE; MATERIALS; METALS; NERVOUS SYSTEM; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RESONANCE; SEPARATION PROCESSES; SPECTRA; TRANSITION ELEMENTS; YIELDS
Optional Information
- Notes
- 17 refs.; 8 figs.