Immune responses to transplatation antigens. Experimental approaches to the induction of allogeneic unresponsiveness in the canine species

Data are presented to give the background of information used for the assessment of the potential applicability of supralethal total-body irradiation and bone-marrow replacement as a technique for the induction of allogeneic unresponsiveness in dogs. Three experimental models for this purpose are described. A table is presented to show the effects of the three methods of host pretreatment for the induction of allogeneic unresponsiveness. The standard and third-party methods induced unresponsiveness to tissues obtained from the donor of marrow. The data were consistent with the possibility that total-body irradiation may induce in the host a privileged phase of altered immunologic reactivity during which antigenic challenge is more likely to produce unresponsiveness than sensitization