Published 2006 | Version v1
Journal article Metadata-only

Synthesis of selank labeled with tritium

Creators

  • 1. RAN, Inst. Molekulyarnoj Genetiki, Moscow (Russian Federation)

Description

Scheme of synthesis of selank (Trh-Lys-Pro-Arg-Pro-Gly-Pro) and its precursor (Thr-Lys-Pro-Arg-Pro-Gly) is developed. Selank labelled in proline C-end is prepared by condensation of tret-butylhydroxycarbonyl derivative Thr-Lys-Pro-Arg-Pro-Gly with labelled proline. Molar radioactivity of selank labelled with tritium is 56 Cu/mmol and that corresponds to molar radioactivity of proline

Abstract (Russian)

Разработана схема синтеза селанка (Trh-Lys-Pro-Arg-Pro-Gly-Pro) и его предшественника (Thr-Lys-Pro-Arg-Pro-Gly). Конденсацией трет-бутилоксикарбонильного производного Thr-Lys-Pro-Arg-Pro-Gly с меченным пролином получен меченный по C-концевому пролину селанк. Молярная радиоактивность меченного тритием селанка равнялась 56 Ки/ммоль, что соответствовало молярной радиоактивности пролина

Additional details

Additional titles

Original title (Russian)
Синтез меченного тритием селанка

Publishing Information

Journal Title
Radiokhimiya
Journal Volume
48
Journal Issue
3
Journal Page Range
p. 267-271
ISSN
0033-8311
CODEN
RADKAU

INIS

Country of Publication
Russian Federation
Country of Input or Organization
Russian Federation
INIS RN
38001986
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
CHEMICAL PREPARATION; LABELLED COMPOUNDS; LABELLING; PEPTIDES; PROLINE; RADIOACTIVITY; RADIOPHARMACEUTICALS; TRITIUM COMPOUNDS
Descriptors DEC
AMINES; AMINO ACIDS; AZOLES; CARBOXYLIC ACIDS; DRUGS; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; LABELLED COMPOUNDS; MATERIALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PROTEINS; PYRROLES; PYRROLIDINES; RADIOACTIVE MATERIALS; SYNTHESIS

Optional Information

Notes
4 refs., 1 fig., 1 tab.