Published September 2006 | Version v1
Journal article Metadata-only

A Nonlinear dynamical model for studying DNA damage-induced p53-Mdm2 interaction

Creators

  • 1. National Laboratory of Heavy Ion Accelerator of Lanzhou, Lanzhou (China). Center of Theoretical Nuclear Physics
  • 2. Beijing Radiation Center, Beijing (China)
  • 3. Beijing Normal Univ., Beijing (China). Inst. of Low Energy Nuclear Physics

Description

Exploring the nonlinear dynamics of the negative feedback loop composed of p53 and Mdm2 proteins, the authors propose a signal-response model to study the dynamical mechanism of the different oscillatory behaviors for the activities of p53 and Mdm2 proteins both in individual and population of cells. It is shown that the sustained and damped oscillatory dynamics could be described in a unified way when the dynamics of damage-derived signal is properly introduced. (authors)

Additional details

Publishing Information

Journal Title
Nuclear Physics Review
Journal Volume
23
Journal Issue
3
Journal Page Range
p. 315-321
ISSN
1007-4627

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
38065630
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
CARCINOMAS; CONCENTRATION RATIO; DNA DAMAGES; DYNAMICS; FEEDBACK; GENE THERAPY; GENES; INHIBITION; NONLINEAR PROBLEMS; OSCILLATION MODES; PROTEINS; RADIATION INJURIES
Descriptors DEC
BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; DIMENSIONLESS NUMBERS; DISEASES; INJURIES; MECHANICS; MEDICINE; NEOPLASMS; ORGANIC COMPOUNDS; RADIATION EFFECTS; THERAPY

Optional Information

Notes
7 figs., 14 refs.