Effect of radioprotectors on the altered DNA content in rat tissues following whole body gamma radiation
Creators
- 1. Institute of Nuclear Medicine and Allied Sciences, Delhi (India)
Description
DNA content in liver spleen and kidney of rats was estimated prior and at 3, 24 and 168 h after 8 Gy whole-body gamma irradiation. As compared to liver and kidney of the irradiated control group, there was a significant decrease in the weight of spleen at 168 h of post irradiation and in its DNA content at all time intervals. Similar studies carried out in animals pretreated with optimum dose of aminoethylisothiuronium bromide hydrobromide (AET, 200 mg/kg body wt.) and with the combination of AET (20 mg/kg body wt.) with 5-hydroxy-L-tryptophan (5-HTP 100 mg/kg body wt.) showed that the altered DNA content in the liver of the irradiated control group was better restored in AET-pretreated group and in case of kidney and spleen by AET + 5-HTP-pretreated group. (author)
Additional details
Publishing Information
- Journal Title
- Radiobiol. Radiother.
- Journal Volume
- 29
- Journal Issue
- 4
- Series
- Radiobiol. Radiother.
- Journal Page Range
- 421-427
- ISSN
- 0033-8184
- CODEN
- RDBGA
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- German Democratic Republic
- INIS RN
- 19099510
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- AET; COBALT 60; DNA; EXPERIMENTAL DATA; GAMMA RADIATION; HYDROXYTRYPTOPHAN; KIDNEYS; LIVER; RATS; SPLEEN; TIME DEPENDENCE; TISSUE DISTRIBUTION; WEIGHT; WHOLE-BODY IRRADIATION
- Descriptors DEC
- AMINES; AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBONIC ACID DERIVATIVES; CARBOXYLIC ACIDS; COBALT ISOTOPES; DATA; DIGESTIVE SYSTEM; DISTRIBUTION; DRUGS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; GLANDS; HYDROXY ACIDS; INFORMATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; NUCLEIC ACIDS; NUMERICAL DATA; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; RADIATIONS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; THIOUREAS; VERTEBRATES; YEARS LIVING RADIOISOTOPES