The influence of low-dose ionized radiation on the marker of astroglial population of the brain cells (Experimental investigation)

The peculiarities of astrocyte response caused by single and fractionated irradiation of rats at a dose of 0.25 Gy during post-radiation period were investigated. Single irradiation was established to elevate soluble glial fibrillar acid protein 12 hours after irradiation in the hippocampus and corpus striatum and on day 5 in the midbrain when compared to the controls. Fractionated irradiation demonstrated less pronounced reverse changes of glial fibrillar acid protein amount when compared with those at single irradiation. Soluble glial fibrillar acid protein increased in the brain neocortex and reduced in the hippocampus and corpus striatum. Our findings show that single and fractionated irradiation at a dose of 0.25 Gy causes the changes in the amount of soluble glial fibrillar acid protein in different structures of the brain of the rats during radiation exposure.