Comparison of various treatment schedules for accelerating the elimination of radioiodine from the thyroid and the human body
- 1. Athens Univ. (Greece). Dept. of Clinical Therapeutics
Description
In 68 euthyroid patients undergoing 131I thyroid function tests the thyroidal, urinary and plasma protein-bound radioactivity has been serially measured for 14 days. The patients were subdivided in controls and 9 groups treated with potassium iodide, carbimazole, potassium perchlorate and TSH, singly or in combination. The aim was to devise a treatment scheme for accelerating the release of iodine from the thyroid and the elimination from the body in cases of accidental radioiodine poisoning if the patient is seen after the radioiodine has already been taken up by the gland. All treatment schedules were effective, but TSH injections gave the best results, especially if combined with carbimazole and potassium perchlorate. This combination is the treatment of choice under these circumstances. (orig.)
Abstract (German)
Bei 68 euthyreoten Patienten wurde nach Verabfolgung von 131J die Radioaktivitaet in der Schilddruese, im Harn und in den Plasmaproteinen bestimmt. Die Patienten waren in 9 Gruppen, die eine Behandlung mit Kaliumjodid, Carbimazol, Kaliumperchlorat und Thyreotropin (TSH) einfach oder kombiniert erhielten und in die Kontrollgruppe geteilt. Unser Ziel war es, ein Behandlungsschema zu finden das eine Beschleunigung der Ausscheidung von Jod aus der Schilddruese und dem Koerper im Falle einer Radiojodvergiftung hervorruft, wenn der Patient nach der Speicherung von Radiojod in der Schilddruese zur Behandlung kommt. Alle Behandlungsschemata waren erfolgreich. Thyreotropin (TSH)-Injektionen geben die besten Ergebnisse, besonders wenn sie mit Carbimazol und Kaliumperchlorat kombiniert werden. Diese Kombination ist die Behandlung der Wahl unter diesen Bedingungen. (orig.)Additional details
Identifiers
Publishing Information
- Journal Title
- Nuklearmedizin
- Journal Volume
- 14
- Journal Issue
- 03
- Series
- Nucl.-Med.
- Journal Page Range
- 219-227
- ISSN
- 0029-5566
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 7240308
- Subject category
- S60: APPLIED LIFE SCIENCES; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ALBUMINS; EXCRETION; GLOBULINS; IODINE 131; PATIENTS; POST-IRRADIATION THERAPY; POTASSIUM IODIDES; POTASSIUM PERCHLORATES; THYROID; TSH; URINE
- Descriptors DEC
- ALKALI METAL COMPOUNDS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY; BODY FLUIDS; CHLORINE COMPOUNDS; CLEARANCE; DAYS LIVING RADIOISOTOPES; ENDOCRINE GLANDS; GLANDS; HALIDES; HALOGEN COMPOUNDS; HORMONES; INORGANIC PHOSPHORS; INTERMEDIATE MASS NUCLEI; IODIDES; IODINE COMPOUNDS; IODINE ISOTOPES; ISOTOPES; MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; OXYGEN COMPOUNDS; PEPTIDE HORMONES; PERCHLORATES; PHOSPHORS; PITUITARY HORMONES; POTASSIUM COMPOUNDS; PROTEINS; RADIOISOTOPES; THERAPY; WASTES
Optional Information
- Notes
- 1 fig.; 3 tabs.; 22 refs.; Updated automatically by Metadata and Full-Text Enrichment Agent