Published October 7, 2019
| Version v1
Journal article
Performance of 99mTc-aprotinin scintigraphy for diagnosing light chain (AL) cardiac amyloidosis confirmed by endomyocardial biopsy
Creators
- 1. Toho University Medical Center Ohashi Hospital. Division of Cardiovascular Medicine (Japan)
- 2. National Center for Global Health and Medicine. Department of Cardiovascular Medicine (Japan)
- 3. National Center for Global Health and Medicine. Division of Nuclear Medicine (Japan)
- 4. The University of Tokyo. Department of Cardiovascular Medicine (Japan)
- 5. Internal medicine Tokyo-Kita Medical Center. Department of Hematology (Japan)
Description
Background
: Light chain (AL) cardiac amyloidosis is associated with a poor prognosis. Diagnosing at an early stage is critical for treatment and the management of cardiac complication.Purpose
: We aimed to evaluate the diagnostic performance of 99mTc-aprotinin images in patients with AL cardiac amyloidosis.Methods and Results
: 99mTc-aprotinin scintigraphy and endomyocardial biopsy were performed in 10 patients with suspected amyloidosis. Endomyocardial biopsy showed amyloid deposits in 5 of 10 patients. 99mTc-aprotinin (planer image) was positive in 4 of 5 patients who had amyloid deposits in endomyocardial biopsy. On the other hand, all 5 patients without amyloid deposits were negative in planer image. 99mTc-aprotinin (SPECT/CT image) was positive in all 5 patients who had amyloid deposits.Conclusions
: 99mTc-aprotinin scintigraphy is valuable for the non-invasive diagnosis of AL cardiac amyloidosis.Additional details
Identifiers
Publishing Information
- Journal Title
- Journal of Nuclear Cardiology (Online)
- Journal Volume
- 27
- Journal Issue
- 4
- Journal Page Range
- p. 1145-1153
- ISSN
- 1532-6551
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 55073205
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BIOPSY; CAT SCANNING; CORONARIES; DEPOSITS; DIAGNOSIS; HEART; IMAGES; MYOCARDIAL INFARCTION; MYOCARDIUM; PATIENTS; SCINTISCANNING; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; TECHNETIUM 99; VISIBLE RADIATION
- Descriptors DEC
- ARTERIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BLOOD VESSELS; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COMPUTERIZED TOMOGRAPHY; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTROMAGNETIC RADIATION; EMISSION COMPUTED TOMOGRAPHY; HEART; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIATIONS; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM ISOTOPES; TOMOGRAPHY; YEARS LIVING RADIOISOTOPES
Optional Information
- Copyright
- Copyright (c) 2019 © American Society of Nuclear Cardiology 2019