Radiographic contrast lienography in experimental diffuse liver lesions

The diagnostic potentialities of i. v. lienography were studied in experiments on rodents during the adm inistration of the liposome forms of radiographic contrast agents (RCA) in the presence of chronic diffuse liver lesion simulated by subcutaneous injection of 50 % oil solution of CCl4 for 2 months. The time-course of splenomegaly was found to be in direct relation to the CCl4 summary dose. The degree of pathomorphological changes of the hepatic tissue and pathological shifts in the blood clinical and biochemical findings show good correlation with the time-course of splenomegaly. The use of the RCA liposome forms extends the range of radiodiagnostic potentialities in the recognition of chronic diffuse liver lesion