Published 1987
| Version v1
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131I Metaiodobenzylguanidine (131I MIBG) kinetics in a carcinoid tumor
Creators
- 1. Rome Univ. (Italy)
Description
The 131I-MIBG kinetics was studied in vivo in patients with carcinoid tumors and liver metastases. Activity curve analysis showed that the maximum uptake of 131I-MIBG in a carcinoid tumor occurred after 48 hours, while its biological half time was of 8 days and a half. Although more data are necessary to understand a significant variation in 131I-MIBG kinetics between the different kinds of APUD neoplasms, it is thought that a dynamic-funtional study allowing the evaluation of the different biological half-time, could be helpful for the selection of these neoplasms, which could be treated with 131I-MIBG. Radiation doses required for the treatment are also estimated. (M.E.L.)
Abstract (Spanish)
Se estudio in vivo la cinetica del 131I-MIBG en pacientes con metastasis hepatica en casos que padecian tumores cancerosos. El analisis de la curva de actividad demostro que la fijacion maxima de 131I-MIBG en un tumor canceroso ocurrio a 48 hs, mientras que el periodo biologico de semidesintegracion fue de 8 dias y medio. A pesar de ser necesarios mas datos para entender si hay una variacion significativa en la cinetica del 131I-MIBG entre las diferentes clases de neoplasmas APUD, se penso que un estudio dinamico-funcional permitiendo la evaluacion de los diferentes tiempos medio biologicos, podria ser util para la seleccion de dichos neoplasmas, los cuales podrian ser tratados con 131I-MIBG y establecer la dosis de radiacion requerida por el tratamiento. (M.E.L.)Files
20084948.pdf
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Additional details
Publishing Information
- Imprint Title
- Progress in radiopharmacology
- Imprint Pagination
- 212 p.
- Journal Page Range
- p. 64-74.
- Report number
- INIS-mf--11544
Conference
- Title
- 5. International symposium on radiopharmacology.
- Dates
- 29-31 Oct 1986.
- Place
- Buenos Aires (Argentina).
INIS
- Country of Publication
- Argentina
- Country of Input or Organization
- Argentina
- INIS RN
- 20084948
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- CARCINOMAS; DYNAMIC FUNCTION STUDIES; GUANIDINES; IODINE; LABELLED COMPOUNDS; LIVER; METABOLISM; METASTASES; RADIONUCLIDE KINETICS; SCINTISCANNING; UPTAKE
- Descriptors DEC
- BODY; CARBONIC ACID DERIVATIVES; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; ELEMENTS; GLANDS; HALOGENS; KINETICS; NEOPLASMS; NONMETALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RADIOISOTOPE SCANNING