Influence of blood viscosity on circulatory parameters determined by first-pass radionuclide angiocardiography in cor pulmonale
Creators
- 1. Dept. of Nuclear Medicine, Pecs (Hungary)
- 2. Dept. of Medicine, Div. of Cardiology Univ. Medical School, Pecs (Hungary)
Description
First-pass radionuclide angiocardiography (FPRNA) with 99mTc-albumin was performed in 19 patients with cor pulmonale. Pulmonary circulation time (PCT), mean transit time (MTT), pulmonary stagnation index (PSI) were calculated from the time-activity curves for the estimation of cardiopulmonary circulation. Whole blood viscosity (WBV), plasma viscosity (PV) and hematocrit (HTC) were also measured on the same day. Significant prolongation of all parameters was observed (WBW: 5,04±1.19 mPAS; PV: 1,36±0,17 mPAS; HTC: 47,6±2,37%; PCT: 7,10±2,15 s; MTT: 9,33±4,11 s; PSI: 1,30±0,37) in patients with cor pulmonale. Significant positive correlations were found between PCT and WBV (r=0,552; 0,001<P<0.01), MTT and WBV (r=0,34; P<0,05), furthermore between PCT and HTC (r=0,356; P<0,05). The results suggest that hemorheological parameters may influence the results of FPRNA, therefore, they should be determined in addition to the radionuclide study. (orig.)
Abstract (German)
Die First-Pass Untersuchung (FPRNA) mit 99mTc-Albumin wurde bei 19 Patienten mit Cor pulmonale durchgefuehrt. Pulmonale Zirkulationszeit (PCT), 'mean transit' Zeit (MTT), pulmonaler Rest Index (PSI) wurden ermittelt aus den Zeit-Aktivitaetskurven zur Einschaetzung des kardiopulmonalen Durchflusses. Vollblut-Viskositaet (WBV), Plasma-Viskositaet (PV) und Haematokrit (HTC) wurden am selben Tage gemessen. Bezeichnend fuer Patienten mit Cor pulmonale war eine typische Vergroesserung aller Parameter (WBV: 5,04±1,19 mPAS; PV: 1,36±0,17 mPAS; HTC: 47,6±2,37%; PCT: 7,10±2,15 s; MTT: 9,33±4,11 s; PSI: 1,30±0,37). Verwertbare Korrelationen wurden zwischen PCT und WBV (r=0,552; 0,001<p<0,01), MTT und WBV (r=0,34; p<0,05) sowie zwischen PCT und HTC (r=0,356; p<0,05) gefunden. Die Resultate zeigen, dass haemorheologische Parameter einen Einfluss auf die Werte der FPRNA haben. Deswegen sollten diese Bestimmungen stets zusammen mit der FPRNA durchgefuehrt werden. (orig.)Additional details
Publishing Information
- Journal Title
- Nuklearmedizin
- Journal Volume
- 32
- Journal Issue
- 6
- Journal Page Range
- p. 288-291.
- ISSN
- 0029-5566
- CODEN
- NUKLDV
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 28061488
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ALBUMINS; BLOOD; BLOOD CIRCULATION; CARDIOVASCULAR DISEASES; DYNAMIC FUNCTION STUDIES; MYOCARDIUM; PATIENTS; RADIOCARDIOGRAPHY; RADIOPHARMACEUTICALS; SCINTISCANNING; TECHNETIUM 99; VISCOSITY
- Descriptors DEC
- ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CARDIOGRAPHY; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; HEART; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MAN; MATERIALS; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PRIMATES; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES