Published August 1984
| Version v1
Journal article
Glutathione depletion in tissues after administration of buthionine sulphoximine
Creators
- 1. Mount Vernon Hospital, Northwood, England
Description
Buthionine sulphoximine (BSO) an inhibitor of glutathione (GSH) biosynthesis, was administered to mice in single and repeated doses. The resultant pattern of GSH depletion was studied in liver, kidney, skeletal muscle and three types of murine tumor. Liver and kidney exhibited a rapid depletion of GSH. Muscle was depleted to a similar level, but at a slower rate after a single dose. All three tumors required repeated administration of BSO over several days to obtain a similar degree of depletion to that shown in the other tissues
Additional details
Publishing Information
- Journal Title
- Int. J. Radiat. Oncol., Biol. Phys.
- Journal Volume
- 10
- Journal Issue
- 8
- Series
- Int. J. Radiat. Oncol., Biol. Phys.
- Journal Page Range
- 1261-1264
- ISSN
- 0360-3016
Conference
- Title
- Conference on chemical modifiers of cancer treatment.
- Dates
- 27 Nov 1983.
- Place
- Banff, Alberta (Canada).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 16030388
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- BIOCHEMISTRY; BIOSYNTHESIS; CARCINOMAS; FIBROSARCOMAS; GLUTATHIONE; IMINES; INHIBITION; KIDNEYS; LIVER; MICE; MUSCLES; RADIOSENSITIVITY
- Descriptors DEC
- ANIMALS; BODY; CHEMISTRY; DIGESTIVE SYSTEM; DISEASES; DRUGS; GLANDS; MAMMALS; NEOPLASMS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PEPTIDES; POLYPEPTIDES; PROTEINS; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; SARCOMAS; SYNTHESIS; VERTEBRATES
Optional Information
- Secondary number(s)
- CONF-8311204--.