Published December 2011
| Version v1
Journal article
In vitro studies of cellular response to DNA damage induced by boron neutron capture therapy
Creators
- 1. National Research Council of Argentina (CONICET), Rivadavia 1917, (1033) Buenos Aires (Argentina)
- 2. Department of Radiobiology, Av. General Paz 1499, San Martin (1560) (Argentina)
- 3. Institute of Oncology "Angel H. Roffo", Av. San Martín 5481, (1417) Cdad. de Buenos Aires (Argentina)
- 4. Department of Instrumentation and Control, Av. General Paz 1499, San Martin (1560) (Argentina)
- 5. RA-3 Reactor, National Atomic Energy Commission (CNEA), Av. General Paz 1499, San Martin (1560) (Argentina)
- 6. Department of Pharmaceutical Chemistry, University of California, San Francisco (United States)
- 7. Department of Biochemistry, UBA, School of Medicine (Argentina)
Description
The aim of these studies was to evaluate the mechanisms of cellular response to DNA damage induced by BNCT. Thyroid carcinoma cells were incubated with 10BPA or 10BOPP and irradiated with thermal neutrons. The surviving fraction, the cell cycle distribution and the expression of p53 and Ku70 were analyzed. Different cellular responses were observed for each irradiated group. The decrease of Ku70 in the neutrons +BOPP group could play a role in the increase of sensitization to radiation.
Availability note (English)
Available from http://dx.doi.org/10.1016/j.apradiso.2011.03.044Additional details
Identifiers
- DOI
- 10.1016/j.apradiso.2011.03.044;
- PII
- S0969-8043(11)00205-3;
Publishing Information
- Journal Title
- Applied Radiation and Isotopes
- Journal Volume
- 69
- Journal Issue
- 12
- Journal Page Range
- p. 1732-1736
- ISSN
- 0969-8043
- CODEN
- ARISEF
Conference
- Title
- 14. international conference on neutron capture therapy
- Dates
- 25-29 Oct 2010
- Place
- Buenos Aires (Argentina)
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 43071815
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- BORON; CARCINOMAS; CELL CYCLE; DNA DAMAGES; IN VITRO; NEUTRON CAPTURE THERAPY; RADIATION INJURIES; THERMAL NEUTRONS; THYROID
- Descriptors DEC
- BARYONS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DISEASES; ELEMENTARY PARTICLES; ELEMENTS; ENDOCRINE GLANDS; FERMIONS; GLANDS; HADRONS; INJURIES; MEDICINE; NEOPLASMS; NEUTRON THERAPY; NEUTRONS; NUCLEAR MEDICINE; NUCLEONS; ORGANS; RADIATION EFFECTS; RADIOLOGY; RADIOTHERAPY; SEMIMETALS; THERAPY
Optional Information
- Copyright
- Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.