Evaluation of Alumina Based 188W/188Re Chromatographic Generators

Within the framework of the coordinated research project, different alumina based 188W/188Re chromatographic generators were prepared and evaluated. The 188W activities loaded into the generators ranged from 200 to 400 mCi, and two different amounts of alumina (2 and 8 g) were used. The lowest 188W breakthrough levels were obtained for the generator containing 8 g of alumina, while the best elution profile corresponded to the 2 g alumina generators. Regarding elution efficiency, the performance of all generators was similar and ranged from 70 to 80% yields of 188Re. The eluate quality was evaluated through the labelling of monoclonal antibodies and diphosphonates. (author)