Published March 1985
| Version v1
Journal article
The induction by 224Ra of myeloid leukaemia and osteosarcoma in male CBA mice
- 1. Medical Research Council, Harwell (UK). Radiobiological Research Unit
- 2. Smith, Kline and French, Welwyn (UK)
Description
Radium-224 was injected into 12-week-old male CBA mice in the range 2-64 kBq per mouse either as a single injection or as eight injections spaced at 3.5 day intervals over 4 weeks. Small but significant yields of myeloid leukaemia or osteosarcoma were obtained in all but the control groups. An effect of mode of administration (single or multiple injections) could not be demonstrated but the combined results showed: (1) a maximum yield of myeloid leukaemia in the region 8-16 kBq 224Ra; (2) a greater yield of osteosarcoma than myeloid leukaemia at 64 kBq 224Ra injected. (author)
Additional details
Publishing Information
- Journal Title
- Int. J. Radiat. Biol. Relat. Stud. Phys., Chem. Med.
- Journal Volume
- 47
- Journal Issue
- 3
- Series
- Int. J. Radiat. Biol. Relat. Stud. Phys., Chem. Med.
- Journal Page Range
- 239-247
- ISSN
- 0020-7616
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 16049988
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ALPHA PARTICLES; BIOLOGICAL RADIATION EFFECTS; DOSE-RESPONSE RELATIONSHIPS; LEUKEMIA; MICE; OSTEOSARCOMAS; RADIUM 224
- Descriptors DEC
- ALPHA DECAY RADIOISOTOPES; ANIMALS; BIOLOGICAL EFFECTS; CHARGED PARTICLES; DAYS LIVING RADIOISOTOPES; DISEASES; EVEN-EVEN NUCLEI; HEAVY NUCLEI; HELIUM IONS; HEMIC DISEASES; IONS; ISOTOPES; MAMMALS; NEOPLASMS; NUCLEI; RADIATION EFFECTS; RADIOISOTOPES; RADIUM ISOTOPES; RODENTS; SARCOMAS; SKELETAL DISEASES; VERTEBRATES