Establishment of SHG-44 human glioma model in brain of wistar rat with stereotactic technique
- 1. Jilin Univ., Changchun (China). First Hospital, Dept. of Neurosurgery
- 2. Jilin Univ., Changchun (China). School of Basic Medical Sciences, Dept. of Pharmacology
Description
Objective: To establish solid intracerebral human glioma model in Wistar rat with xenograft methods. Methods: The SHG-44 cells were injected into brain right caudate nucleus of previous immuno-inhibitory Wistar rats with stereotactic technique. The MRI scans were performed at 1 week and 2 weeks later after implantation. After 2 weeks the rats were killed and pathological examination and immunohistologic stain for human GFAP were used. Results: The MRI scan after 1 week of implantation showed the glioma was growing, pathological histochemical examination demonstrated the tumor was glioma. Human GFAP stain was positive. The growth rate of glioma model was about 60%. Conclusion: Solid intracerebral human glioma model in previous immuno-inhibitory Wistar rat is successfully established
Additional details
Publishing Information
- Journal Title
- Journal of Jilin University. Medicine Edition
- Journal Volume
- 30
- Journal Issue
- 2
- Journal Page Range
- p. 224-226
- ISSN
- 1671-587X
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 36045944
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BIOLOGICAL MODELS; BRAIN; DIAGNOSIS; GLIOMAS; HISTOLOGICAL TECHNIQUES; NEOPLASMS; NMR IMAGING; RATS
- Descriptors DEC
- ANIMALS; BODY; CENTRAL NERVOUS SYSTEM; DIAGNOSTIC TECHNIQUES; DISEASES; MAMMALS; NEOPLASMS; NERVOUS SYSTEM; NERVOUS SYSTEM DISEASES; ORGANS; RODENTS; VERTEBRATES