Published December 15, 2000
| Version v1
Journal article
Studies on the preparation and stability of samarium-153 propylene diamine tetramethylene phosphonate (PDTMP) complex as a bone seeker
Description
Propylene diamine tetra methylene phosphonate (PDTMP) was synthesised by modifying a method reported for the synthesis of EDTMP. Complexation of the synthesised phosphonate ligand with 153Sm was carried out by varying the experimental parameters and the complex was radiochemically characterized. Biodistribution studies showed that the uptake by bone in rats was 2% per g of bone, which was retained up to 48 h. The uptake by other organs was insignificant, except by the liver which showed a slightly higher absorption
Additional details
Identifiers
- PII
- S0969804399002705;
Publishing Information
- Journal Title
- Applied Radiation and Isotopes
- Journal Volume
- 53
- Journal Issue
- 6
- Journal Page Range
- p. 987-991
- ISSN
- 0969-8043
- CODEN
- ARISEF
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- Belarus
- INIS RN
- 33030258
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- AUTORADIOLYSIS; BONE SEEKERS; LIGANDS; PHOSPHONATES; PROPYLENE; PUTRESCINE; RADIOPHARMACEUTICALS; SAMARIUM 153; UPTAKE
- Descriptors DEC
- ALKENES; AMINES; AUTOLYSIS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHEMICAL RADIATION EFFECTS; CHEMICAL REACTIONS; DAYS LIVING RADIOISOTOPES; DECOMPOSITION; DRUGS; EVEN-ODD NUCLEI; HYDROCARBONS; INTERMEDIATE MASS NUCLEI; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NUCLEI; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; RADIATION EFFECTS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RADIOLYSIS; RARE EARTH NUCLEI; SAMARIUM ISOTOPES
Optional Information
- Copyright
- Copyright (c) 2000 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.