Serum trypsin inhibitory capacity in hemodialysis patients
Creators
- 1. Dept. of Clinical Biochemistry, Zahedan Univ. of Medical Sciences, Zahedan (Iran, Islamic Republic of)
- 2. Research Center for Infectious Diseases and Tropical Medicine, Bou Ali Hospital, Zahedan Univ. of Medical Sciences, Zahedan (Iran, Islamic Republic of)
- 3. Dept. of Nutrition, School of Medicine, Zahedan Univ. of Medical Sciences, Zahedan (Iran, Islamic Republic of)
- 4. Manitoba Inst. of Cell Biology and Dept. of Biochemistry and Medical Genetics, Univ. of Manitoba, Winnipeg (Canada)
Description
It has been established that overproduction of reactive oxygen species (ROS) occurs during hemodialysis causing oxidation of proteins. Alpha-1-antitrypsin is the major circulating anti-protease which contains methionine in the active site. The aim of the present study was to measure the level of serum trypsin inhibitory capacity (sTIC) in hemodialysis patients. This case-control study was performed in 52 hemodialysis patients and 49 healthy controls. sTIC was measured by enzymatic assay. The sTIC was significantly (P< 0.001) lower in hemodialysis patients (1.87 + - 0.67 micron mol/min/mL) than healthy controls (2.83 + - 0.44 micron mol/min/L). Reduction of sTIC may be due to the oxidation of methionine residue in the reactive site of alpha-1 antitrypsin. (author)
Additional details
Publishing Information
- Journal Title
- Saudi Journal of Kidney Diseases and Transplantation
- Journal Volume
- 20
- Journal Issue
- 4
- Journal Page Range
- p. 604-607
- ISSN
- 1319-2442
INIS
- Country of Publication
- Saudi Arabia
- Country of Input or Organization
- Saudi Arabia
- INIS RN
- 40106123
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- METHIONINE; OXIDATION; PATIENTS; PROTEINS
- Descriptors DEC
- AMINO ACIDS; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; DRUGS; LIPOTROPIC FACTORS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS